Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2.

J Med Chem · 2025 · PMC12434667 · PMID 40833690

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a clear trendno p-value reported

Modeling analysis indicated a clear trend in decreasing 3D-PSA for compounds 9 – 11 compared to 8 , thereby impacting permeability and consequently oral absorption.

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