Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential.

Logistic regression revealed a significant trend of decreasing GD risk from the first (Q1) to the third (Q3) quintiles of indirect bilirubin levels, with ORs of 0.928 (95% CI 0.887 to 0.969, p=4.20×10−4) for Q2 and 0.945 (95% CI 0.900 to 0.990, p=1.87×10−2) for Q3 compared with Q1.

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