Ap1s1 reduction in the aging brain heightens neuronal vulnerability to amyloid-β and oxidative stress in Alzheimer's pathogenesis.

Additionally, there was a decreasing trend in the mRNA levels of Htr2a , Wwtr1 , and Nudt21 from 12 to 18 months of age, but without significant differences (Fig. 3 G).

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Moreover, although there was a downward trend in the time spent in the target quadrant, this difference did not reach statistical significance (Fig. 4 B).

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