HLA-B*15:01-positive severe COVID-19 patients lack CD8<sup>+</sup> T cell pools with highly expanded public clonotypes.

In the Japan cohort ( 25 ), we observed an enrichment of HLA-B*15:01 + individuals reporting symptomatic infection (symptomatic frequency = 0.07, asymptomatic frequency = 0.05), with an odds ratio of 0.65, albeit this did not reach statistical significance (95% CI = 0.89 to 0.48, P = 0.17, P adj = 1) ( Fig. 4 B and SI Appendix , Table S6 ).

also in 111,027 other papers