Co-mutation of PCLO and SYNE1 defines an immune-activated endometrial cancer subtype with favorable prognosis.

10 We observed a highly significant co‐occurrence of PCLO and SYNE1 mutations in EC.

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Although the co‐mutation did not reach statistical significance in the multivariate Cox regression after adjusting for POLE status, stage, grade, and TMB, the co‐mutation was associated with robust immunogenic features—high TMB, low aneuploidy, immune‐inflamed TME, and strong cytotoxic effector enrichment—which were all mechanistically relevant to survival.

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