Inflammation-metabolite crosstalk in multiple sclerosis: A mediation Mendelian randomization study of plasma inflammatory proteins, iron, and serum/cerebrospinal fluid metabolites.

Sci Prog · 2025 · PMC12437195 · PMID 40953052

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failed to reach significanceno p-value reported

56 Notably, some initially identified metabolites, including TDC, albumin levels, and leucine-to-phosphate ratio, failed to reach significance in BWMR, possibly due to residual pleiotropy or limited statistical power.

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nominally significantno p-value reported

Among the metabolites analyzed, taurocholenate sulfate (OR = 1.16, 95% CI: 1.00–1.35, p = 0.047), anthranilate (OR = 1.19, 95% CI: 1.03–1.38, p = 0.020), and sphingomyelin (d18:1/24:1, d18:2/24:0) (OR = 1.001, 95% CI: 1.000–1.002, p = 0.028) demonstrated nominally significant associations with MS risk.

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