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Efficacy of Topiramate in Treating Methamphetamine Use Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Eur Psychiatry · 2025 · PMC12437485

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showed a trendno p-value reported
Conclusions For patients with methamphetamine use disorder, topiramate did not increase abstinence rates when compared to placebo, but showed a trend towards improving depressive symptoms.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.