Efficacy of Methylphenidate in Patients With Brain Disease: A Systematic Review and Meta-Analysis.

Brain Neurorehabil · 2025 · PMC12438567 · PMID 40963945

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hedged sentence

0.1600

closest p · 3.2× alpha

0.1600

boldest claim

The sentences

did not reach statistical significancep = 0.16not close (p > 0.1)

Changes in executive function with methylphenidate use did not reach statistical significance (SMD, 1.62; 95% CI, −0.65 to 3.89; p = 0.16; I 2 = 91.21%) ( Fig. 2D ).

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