Suppnonsense-mediated decay-linked mutations in SARS-CoV-2 and their association with COVID-19 disease severity.

BMC Infect Dis · 2025 · PMC12439368 · PMID 40958107

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.1640

boldest claim

The sentences

highly significantp < 0.001actually significant

Among these: Variants 5, 6, 7, 9, and 15 showed highly significant associations with disease severity ( p < 0.001).

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a trend toward significancep = 0.078so close (0.05 < p ≤ 0.1)

showed a trendp = 0.078so close (0.05 < p ≤ 0.1)

Age showed a trend toward significance ( p = 0.078), indicating a possible increase in risk with advancing age, though not reaching conventional significance.

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did not reach statistical significancep = 0.164not close (p > 0.1)

Association between viral lineage and disease severity When WHO variant was modeled as the primary exposure (Delta as the reference), Omicron infection was associated with 1.91 times higher odds of severe disease compared to Delta, although this did not reach statistical significance (95% CI: 0.77–4.77, p = 0.164).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.