Consistent with clinical observations, patients with MF or SMF showed a trend of higher ZRSR2 VAF and elevated platelet counts, as well as a trend of lower hemoglobin levels and white blood cell counts (Supporting Information: Figure S8 ).
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ZRSR2 loss causes aberrant splicing in JAK2<sup>V617F</sup>-driven myeloproliferative neoplasm but is not sufficient to drive disease progression.
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