Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications.

Invest Ophthalmol Vis Sci · 2025 · PMC12439503 · PMID 40938073

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hedged sentences

0.0571

closest p · 1.1× alpha

0.0571

boldest claim

The sentences

borderline significantP = 0.0571so close (0.05 < p ≤ 0.1)

Deamidation was the next most abundant PTM and showed differences based on both age and solubility, with YWS versus OWS, OWS versus OWI, and YWI versus OWI comparisons all being significant ( P < 0.05) and the YWS versus YWI comparison being borderline significant ( P = 0.0571; see Fig. 2 B).

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did not reach statistical significanceno p-value reported

Formylation also appeared to show a trend of lower abundance in the WI fractions of both age groups, but this did not reach statistical significance (see Fig. 2 F).

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a slight trendno p-value reported

Oxidation was the most abundant PTM and appeared to have a slight trend of increased frequency in the WI fraction, but this was not statistically significant (see Fig. 2 A).

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