A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death.

PLoS One · 2025 · PMC12440158 · PMID 40956795

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slightly significantno p-value reported

By contrast the addition of nivolumab to SW480 cells had only a slightly significant effect at 72 hours with 25 μM NUC-3373 pre-treatment.

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