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LC-MS-Based Serum Metabolomic Analysis Predicts the Risk of Tigecycline-Induced Coagulopathy in Critically Ill Patients.

Drug Des Devel Ther · 2025 · PMC12442925 · PMID 40969845

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Furthermore, During the 14-day post-discontinuation follow-up, key coagulation parameters (eg, aPTT, PT, TT, and Fib) of 70.2% TIC patients showed a trend toward normalization within 5 days after tigecycline discontinuation, which was consistent with previously published studies. 12 , 29 Serum Metabolic Traits A total of 159 serum samples from 53 critically ill patients (three samples per patient) were analyzed to investigate the serum metabolic traits of the non-TIC and TIC groups.

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