A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.

Nat Aging · 2025 · PMC12443628 · PMID 40913219

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Meanwhile, patients carrying LRRK2 G2019S at visit 1 showed a trend of downregulation of longer genes compared to shorter genes, but the test was not statistically significant (median length of upregulated genes, 12,216 bp; median length of downregulated genes, 17,417 bp; Wilcoxon P = 0.2509) (Extended Data Fig. 7b,c ).

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