The influence of morphine treatment on the opioid propeptide gene expression in the forebrain of two inbred mouse strains with different sensitivity to opioids.

Pharmacol Rep · 2025 · PMC12443941 · PMID 40810763

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hedged sentences

0.0000

closest p · 0.0× alpha

0.0580

boldest claim

The sentences

highly significantp = 2.2×10 −16actually significant

The two-way ANOVAs demonstrated highly significant differences between the strains ( Pdyn F 1,216 = 79.25, p = 2.2×10 −16 ; Penk F 1,213 = 60.19, p = 3.54×10 −13 for the strain factor) and a significant interaction of both factors (strain x brain region: Pdyn F 3,216 = 8.79, p = 1.6×10 −5 ; Penk F 3,213 = 5.36, p = 1.4×10 −3 ).

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close to significancep = 0.051so close (0.05 < p ≤ 0.1)

In the dStr, morphine treatment augmented Penk expression in the DBA strain (significant treatment factor: F 1,35 = 6.42, p = 0.016), and a similar trend was observed in the C57 strain with the p-value close to significance (F 1,35 = 4.1, p = 0.051).

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approached significancep = 0.058so close (0.05 < p ≤ 0.1)

3 A, B, D), whereas in the NAc shell the treatment effect approached significance (F 1,66 = 3.73, p = 0.058) (Fig. 3 C).

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