Prognostic significance of tumour Ki-67 dynamics during neoadjuvant treatment in patients with breast cancer: a population-based cohort study.

Lancet Reg Health Eur · 2025 · PMC12444493 · PMID 40980814

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did not reach statistical significanceno p-value reported

The test for interaction did not reach statistical significance (p int = 0.099), with interaction-term HR of 0.995 (95% CI: 0.984–1.007) for HER2+ and 0.989 (95% CI: 0.980–0.999) for TNBC.

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highly significantno p-value reported

We demonstrated that there is a highly significant prognostic association between relative change of Ki-67 and the examined survival outcomes across the whole cohort and per subtype analysis including HER2+ BC.

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