Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity.

However, when the cultures were treated with OI or DMF, a known Nrf2 activator, we observed significantly increased expression of EpoR , Gata1 , and Cpox with OI, whereas DMF significantly increased EpoR and showed a trend toward increased Gata1 and Cpox mRNA expression ( Figure 7C ).

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