Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda.

Similarly, IPTp with dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine was associated with a higher risk of the composite adverse birth outcome compared to sulfadoxine–pyrimethamine alone, although this difference did not reach statistical significance (255 [30.0%] of 850 versus 222 [26.4%] of 842; RR 1.14 [95% CI 0.98–1.33], p = 0.10) ( Fig 2B ).

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