Research advances in treatment strategies for breast cancer liver metastases: A comprehensive review.

Although this did not reach statistical significance, the trend towards clinical benefit has been included in the NCCN guidelines recommendations. 31 Isapretilone is the first novel antitumor drug in the epothilone class, it binds to tubulin and prevents cancer cells from undergoing mitosis, ultimately leading to the apoptosis of tumor cells. 32 , 33

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