Meta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus.

In addition, difelikefalin demonstrated a trend toward reducing the Skindex-10 score in comparison with nalbuphine, though this did not reach statistical significance ( P for interaction = 0.117). 100-mm VAS Score Three articles were separated into 5 studies based on the different drug doses used, all of which included nalfurafine as the drug intervention and the 100-mm VAS score as an outcome, involving 667 patients with CKD-aP.

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