Modulation of Amyloid-β Aggregation by Surface Proteins from Pathogens Associated with Alzheimer's Disease.

Additionally, since the results from OspA and OspC treatment showed an apparent trend in APP accumulation compared to the strong cellular response induced by HSV-1 infection, we investigated whether OspA and OspC treatments stimulated the secretion of Aβ40 and Aβ42 peptides, which were shown to exhibit antimicrobial activity in in vivo and in vitro models. , We also evaluated the ratio of Aβ42/40 in the secreted neuronal cultures, as it serves as an indicator of ongoing AD-like pathology in in vitro neuronal models, as previously shown by us and others and reviewed in ref .

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On the other hand, treatment with OspA resulted in a moderate increase in APP signal, accompanied by a trend toward APP clustering, although this trend did not reach statistical significance ( Figure b–d).

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