Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial.

Stroke · 2025 · PMC12447817 · PMID 40718899

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near-significantno p-value reported

In the per-protocol analysis, there was a near-significant unadjusted 6.1% reduction in WMH volume with tadalafil compared with placebo, suggesting a potential therapeutic effect.

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