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Comparative Risk of Atrial Fibrillation Onset in Statin-Treated Patients Initiating Icosapent Ethyl and Omega-3 Acid Ethyl Esters: A Retrospective Cohort Study.

J Am Heart Assoc · 2025 · PMC12450000 · PMID 40673511

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However, the study result showed a higher incidence of AF in the n‐3 polyunsaturated fatty acids treated group, although this difference did not reach statistical significance. 10 In an observational study (MESA [Multi‐Ethnic Study of Atherosclerosis]) on individuals without cardiovascular disease, higher plasma levels of DHA (but not EPA only or EPA in combination with DHA) were associated with a lower risk of incident AF. 11 A recent systematic review and meta‐

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