Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.

The intergroup difference was marginally significant in the left hippocampus ( p = 0.05) and significant in the right hippocampus ( p < 0.001) (Figure 4 ). 3.5 Age Subgroup The pooled effect size was large for both the left (SMD = −1.25 [−1.64 to −0.86]) and right (SMD = −0.93 [−1.43 to −0.42]) hippocampi in the age >72 years subgroup.

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For the right side, Egger's test also indicated significant small‐study effects ( β = −15.77, z = −2.57, p = 0.010), though Begg's test did not reach statistical significance (Kendall's score = −11.00, z = −1.51, p = 0.209).

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