After 4 weeks of UV exposure, the gene and protein expression levels of TGFBR1, TGFBR2, SMAD2, SMAD3, and SMAD4 in the model group showed a decreasing trend compared to the control group.
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Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
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Furthermore, compared to week 4, the CCA group showed a trend of improvement over the control group at week 9 (Fig. 4 A), suggesting that long-term oral administration of CCA may enhance the body's antioxidant capacity to prevent UV-induced oxidative stress damage.