a significant trendp -value < 0.0001
The KM curves indicated there was a separation of survival probabilities for PFS among the C ave,day28 , C ave,day42 , C ave,day56 , and C ave,day70 quartiles, and there was a significant trend of survival benefit of PFS for the higher exposure quartile (Q4 > Q3 > Q2 > Q1, p -value < 0.0001).