Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.

38 , 39 Interestingly, though not significant, DHA-gly-induced decrease in APD 90 showed a trend to be greater in LQT2 than in WT VCMs (delta APD 90 , WT: −35.3 ± 12.1 ms; LQT2: −70.4 ± 30.4 ms) (see Supplementary material online , Figure S3E ).

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