Investigating causal effects of HDL-C on cognitive function through cross-sectional and Mendelian randomization analyses: concentration-response patterns and clues for Alzheimer's disease prevention.

BioData Min · 2025 · PMC12455801 · PMID 40983978

Europe PMC DOI

hedged sentences

0.0190

closest p · 0.4× alpha

0.0530

boldest claim

The sentences

nominally significantp = 0.019actually significant

The initial IVW analysis revealed a nominally significant negative association between HDL-C and AD (OR = 0.51, 95% CI 0.29–0.89, p = 0.019), suggesting a potential protective effect of HDL-C.

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marginally significantp = 0.053so close (0.05 < p ≤ 0.1)

In the male group, the standard linear model showed a significant positive correlation between HDL-C and AFT (β = 0.22, 95% CI 0.07–0.37, p = 0.005) and a marginally significant positive correlation with DSST (β = 0.11, 95% CI 0.00–0.22, p = 0.053), and a positive correlation with Sum_Score_Z (β = 0.42, 95% CI 0.02–0.81, p = 0.038).

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