Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress.

BMC Med · 2025 · PMC12455811 · PMID 40983918

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Furthermore, eWAT from mice depleted of both STK25 and MST3 displayed up-regulated Ucp1 mRNA levels and showed a trend toward higher mitochondrial content, compared to controls (Additional File 2: Supplementary Fig.

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