Novel Causal Evidence for the Role of Circulating Lipid Metabolites in Breast Cancer Risk: A Bidirectional Mendelian Randomization Analysis.

In the primary MR analysis, 24 lipid metabolites showed nominally significant associations ( p < 0.05) with the risk of ER+ breast cancer ( Table S3 , Figure 2(a) ), while 23 metabolites were similarly associated with ER− breast cancer ( Table S4 , Figure 2(b) ).

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