Examination of oxidative stress and glutamate as potential mechanisms of N-acetylcysteine in the treatment of non-suicidal self-injury in young people assigned female at birth: randomised trial.

In keeping with a previous open-label study demonstrating reductions in depression severity and NSSI following 8 weeks of oral NAC in youth with NSSI, 18 we again showed similar trends in clinical improvement, but, because all three groups showed a trend for decreases in NSSI frequency and depression, attribution of these changes to NAC (versus non-specific effects of being in the clinical trial) could not be confirmed.

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