Reduced Versus Full-Dose Direct Oral Anticoagulants for Venous Thromboembolism in Cancer Patients: A Systematic Review and Meta-Analysis.

EJHaem · 2025 · PMC12459301 · PMID 41000253

Europe PMC DOI

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a favorable trendno p-value reported

Interestingly, reduced doses were associated with a significant reduction in incidental or asymptomatic VTE, and a favorable trend was observed in composite bleeding outcomes, including a statistically significant reduction in combined major and CRNMB events.

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did not reach statistical significanceno p-value reported

[ 10 ] observed a trend toward reduced bleeding with reduced‐dose DOACs, but this did not reach statistical significance.

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