IGF-1 downregulates matrix metalloproteinase 8 to promote plaque stability: Evidence from myeloid cell-specific MMP8 in atherosclerosis.

PLoS One · 2025 · PMC12459808 · PMID 40991633

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hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

a strong trendp = 0.052so close (0.05 < p ≤ 0.1)

Also, by quantification made under polarized light, the same group had a strong trend of collagen increase (p = 0.052) in IGF-1 treated animals ( Fig 5C ).

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a slight trendno p-value reported

Although we did not see any change in necrotic core size, we did see a slight trend increase of fibrotic cap thickness in mice with MF MMP8 deficiency ( Fig 5D , E ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.