BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states.

Nat Metab · 2025 · PMC12460178 · PMID 40957995

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Genetic manipulation of RAB7 levels or activity in MES cells did not induce lysosomal acidification, whereas RAB7-T22N showed a trend toward further alkalinization of the lysosomal pH (Extended Data Fig. 4h ).

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