Taohong Siwu Decoction alleviates high salt-induced calcium overload and ferroptosis in vascular endothelial cells in hypertension by regulating ATF4.

Although incubation with both 2.5 and 3.75% THSWD-containing serum also lowered ROS levels, these results did not reach statistical significance ( Figures 10I , J ). siATF4 downregulated the protein and mRNA expression of ACSL4 and LPCAT3 ( p < 0.05).

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Mice fed with a high-salt diet showed a decreasing trend in blood pressure after receiving high-dose THSWD, low-dose THSWD, and nifedipine treatment starting from the 9th week, approaching the blood pressure level of the mice in normal group by the 12th week, compared to the HSD group mice, there was a significant decrease in blood pressure ( p < 0.05) ( Figure 1A ).

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