CAR T cell engineering impacts antigen-independent activation and co-inhibition.

Mol Ther Methods Clin Dev · 2025 · PMC12464704 · PMID 41020262

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While all clusters were found with both CAR constructs and production modes, SB-manufactured T cells showed a trend toward expanded proliferative CD4 + /CD8 + γδ T cells with high expression of KLRF1 (proliferation cluster 2; Figures 4 A and 4B).

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