Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner.

6 B) with a statistically nonsignificant trend toward longer latency in Ctl mice on HFD compared with Ctl mice fed on CD ( p = 0.13) and a nonsignificant trend of shorter latency in TLR4-MKO mice versus Ctl mice under the HFD condition ( p = 0.11).

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There was also a main effect of diet on F4/80 levels ( F (1, 28) = 5.462, p = 0.027), though between group analyses did not reach statistical significance in either Ctl or TLR4-MKO mice.

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