A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals.

BMC Nephrol · 2025 · PMC12465664 · PMID 41013308

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

a clear trendno p-value reported

A clear trend was not observed when examining the CKD-PRS deciles with the blood pressure traits nor was statistically significant improvement in AUC was observed (Fig. 1 ; Supplementary Tables S3 - 5 , Additional File 1 ).

also in 19,460 other papers

a positive trendno p-value reported

Additionally, a positive trend was observed between higher SBP-PRS deciles and the odds of HT as well as with mean SBP and DBP; the individuals in the highest SBP-PRS decile had 5-fold increased odds for having HT as compared to the individuals in the lowest decile (95% CI: 3.32–7.93) and had an estimated increase of 16.51 mmHg (95% CI: 13.43–19.60) and 6.66 mmHg (95% CI: 4.89–8.43) in SBP and DBP, respectively (Fig. 2 ; Supplementary Tables S6 - 9 , Additional File 1 ).

also in 11,005 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.