Sustained release of exogeneous fetuin-A from Hyaluronic acid microplates decreases joint degeneration, synovial hyperplasia and muscle damage in a murine post-traumatic osteoarthritis model.

In line with this premise, initial animal studies in a surgical PTOA model showed that single fetuin-A delivery into OA knees significantly reduced inflammation; however, although decreased articular cartilage damage was observed in fetuin-A treated knees, differences did not reach statistical significance [ 14 ].

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