STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity.

Sci Adv · 2025 · PMC12466853 · PMID 41004572

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a decreasing trendno p-value reported

did not reach statistical significanceno p-value reported

To further investigate this, we analyzed tumor-infiltrating immune cell populations and observed a significant increase in M2-like TAMs in MC38 tumors from LysM Cre Stk11 fl/fl mice, while M1-like TAMs exhibited a decreasing trend that did not reach statistical significance (fig.

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