Synergistic Induction of Apoptosis by Boswellic Acid and Cisplatin in A549 Lung Cancer Cells Through NF-κB Modulation and p53 Pathway Activation.

Compared to the control, the AKBA + Cis combination induced a highly significant increase in p53 ( p < 0.001) and caspase-3 ( p < 0.001), and a significant decrease in NF-κB expression ( p < 0.001).

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Quantification of Cytokine Levels in A549 Cells Treated with AKBA and Cis Cytokine analysis demonstrated that the levels of IL-1β, IL-6, and TNF-α were significantly reduced in the combination therapy group compared to the control group, whereas reductions in some monotherapy groups did not reach statistical significance.

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