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Real-World Outcomes Between Perioperative Chemotherapy (FLOT) and Preoperative Concurrent Chemoradiotherapy (CROSS) in Localized Esophageal and Esophagogastric Junction Adenocarcinoma: A Retrospective Cohort Study.

Cancers (Basel) · 2025 · PMC12468997 · PMID 41008806

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showed a trendno p-value reported
Importantly, patients who underwent surgery after CROSS showed a trend toward improved OS compared with those who did not (44.1 vs. 19.6 months), reaffirming the critical role of surgery in achieving durable outcomes in this complex disease setting.

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