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<i>BDNF</i> Val66Met Genotype, DNA Methylation, mRNA, and Protein Levels as Potential Blood-Based Biomarkers for Dementia and Cognitive Decline.

Int J Mol Sci · 2025 · PMC12470092 · PMID 41009553

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showed a trendno p-value reported
Moreover, using this model, lower methylation in BDNF_IV1 also had significant predictive value for dementia ( p = 0.009; Table 2 ), although lower BDNF_IV1 methylation in dementia patients only showed a trend when participants were compared directly ( Figure 1 , Supplementary Table S2 ).

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