Prognostic Role of MMP2, MMP9, and IL-1β Markers in Cardiac Allograft Rejection After Transplantation.

Int J Mol Sci · 2025 · PMC12470548 · PMID 41009699

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0700

boldest claim

The sentences

borderline significantp ≈ 0.05actually significant

Nuclear MMP9 expression correlated with ACR and immune cell markers and was borderline significant for AMR ( p ≈ 0.05).

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did not reach statistical significancep = 0.0700so close (0.05 < p ≤ 0.1)

Although MMP2 expression was significantly associated with the degree of pAMR, when examined alone, associations with specific immune cell markers linked to humoral rejection—CD4, cluster of differentiation 8 (CD8), and CD68—did not reach statistical significance ( p = 0.0700, p = 0.0700, and p = 0.1900, respectively).

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a notable trendno p-value reported

However, a closer analysis of our cohort revealed a notable trend: MMP2 expression was more consistently associated with AMR grades than with ACR, particularly when its cytoplasmic positivity was >50%.

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a positive trendno p-value reported

In addition, <50% nuclear positivity exhibited a positive trend (OR = 2.27), although it did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.