Barely Significant
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p.N370S <i>GBA1</i> Mutation Influences the Morphology and Lipid Composition of Extracellular Vesicles in Blood Plasma from Patients with Parkinson's Disease.

Int J Mol Sci · 2025 · PMC12470647 · PMID 41009720

Europe PMCDOI
2
hedged sentences
0.0000
closest p · 0.0× alpha
0.0880
boldest claim

The sentences

highly significantp = 1.37 × 10 −9actually significant
Pairwise group comparisons using Fisher’s exact test revealed a highly significant difference in the morphology of EVs between patients with GBA1-PD carrying the p.L444P and p.N370S mutations ( p = 1.37 × 10 −9 ).

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did not reach statistical significancep = 0.088so close (0.05 < p ≤ 0.1)
The difference between GBA1-PD patients carrying the p.L444P and controls did not reach statistical significance ( p = 0.088), whereas the difference between GBA1-PD patients carrying the p.N370S carriers and controls was significant ( p = 0.0108) ( Figure 3 E).

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