Barely Significant
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<i>Premna puberula</i> P. Ethyl Acetate Extract Treats Ulcerative Colitis by Regulating the Intestinal Flora and Improving Serum Metabolism.

Molecules · 2025 · PMC12472188 · PMID 41011701

Europe PMCDOI
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did not reach statistical significancep = 0.10so close (0.05 < p ≤ 0.1)
Although permutational MANOVA (adonis) based on Bray–Curtis distances did not reach statistical significance ( p = 0.10), the effect size (R 2 = 0.312) suggests a biologically relevant separation between MC and PPEAC-H.

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a decreasing trendno p-value reported
Our findings revealed a decreasing trend in DAI scores among UC mice treated with PPEAC, suggesting that PPEAC exerts a therapeutic effect on UC, a conclusion that aligns with the research conducted by Ruan [ 14 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.