Anti-Obesity, Lipid-Lowering, and Anti-Hyperglycemic Effects of CB-02 in High-Fat-Diet-Induced Obese Mice.

The relative spleen weight showed a decreasing trend after CB-02 and orlistat administration (G3, G4, and G5), though it was not statistically significant, possibly due to the longer time required to reverse obesity-induced splenic alterations.

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The relative weight of the pancreas in the model group (G2) tended to decrease compared to the control group (G1), while treatment with CB-02 (G4 and G5) showed a trend toward increased pancreatic weight relative to the model group (G2); however, these differences were not statistically significant ( p > 0.05).

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