Maternal Folic Acid Supplementation, Perinatal Factors, and Pre-Adolescent Asthma: Findings from the Healthy Growth Study.

Although a slightly higher prevalence of asthma was noted among pre-adolescents whose mothers took folic acid during pregnancy, compared with those without asthma, this difference did not reach statistical significance across the first (18.9% vs. 15.3%, p = 0.059), second (25.1% vs. 20.9%, p = 0.054), or third trimester (23.6% vs. 19.6%, p = 0.059).

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Moreover, the associations reported are modest and often borderline significant and should be interpreted with caution.

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