Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson's disease and dementia with Lewy bodies.

Gba mice showed a trend towards increased clasping, whereas Gba-SNCA mice showed a significant increase across all ages, indicating a synthetic motor phenotype (Fig. 1C and Supplementary Fig. 1H ).

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While the DEGs were highly significant and consistently changed, many genes in the Gba mutants did not exhibit large fold changes versus controls.

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