Management of hepatotoxicity associated with CDK4/6 inhibitors and rechallenge strategies in metastatic hormone-positive, HER2-NEGATIVE BREAST CANCER.

J Cancer Res Clin Oncol · 2025 · PMC12476334 · PMID 41014426

Europe PMC DOI

hedged sentence

0.0960

closest p · 1.9× alpha

0.0960

boldest claim

The sentences

did not reach statistical significancep = 0.096so close (0.05 < p ≤ 0.1)

The median time to hepatotoxicity onset was shorter in corticosteroid-treated patients (45.5 days, IQR: 12.25–149.25) compared to those not receiving corticosteroids (84 days, IQR: 39–361), although this difference did not reach statistical significance ( p = 0.096).

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